AIM-100

Product Name: AIM-100
CAS No.: 873305-35-2
Chemical Name: AIM-100
Synonyms: AIM-100;AIM 100;AIM100;(S)-5,6-Diphenyl-N-[(2-tetrahydrofuryl)methyl]furo[2,3-d]pyrimidin-4-amine;(S)-5,6-Diphenyl-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine;5,6-Diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]furo[2,3-d]pyrimidin-4-amine;Furo[2,3-d]pyrimidin-4-amine, 5,6-diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]-;TMPRSS2,AIM-100,AIM 100,Inhibitor,Ack1,NKX3.1,TNK2,ATM,Activated Cdc42 kinase 1,Tyr-phosphorylation,PSA,Tyr267,inhibit,anticancer
CBNumber: CB72624072
Molecular Formula: C23H21N3O2
Formula Weight: 371.43
MOL File: 873305-35-2.mol

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AIM-100 Property

Boiling point:: 552.9±50.0 °C(Predicted)
Density: 1.243±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: insoluble in H2O; ≥35.8 mg/mL in EtOH with gentle warming; ≥36 mg/mL in DMSO with gentle warming
form: Powder
pka: 4.62±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29487
Product name: AIM 100
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 29487
Product name: AIM 100
Packaging: 50mg
Price: $456
Updated: 2024/03/01

Cayman Chemical

Product number: 29487
Product name: AIM 100
Packaging: 10mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 29487
Product name: AIM 100
Packaging: 25mg
Price: $343
Updated: 2024/03/01

Tocris

Product number: 4946
Product name: AIM100
Purity: ≥98%(HPLC)
Packaging: 10
Price: $214
Updated: 2021/12/16

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AIM-100 Chemical Properties,Usage,Production

Uses

AIM-100 modulates ligand-independent AR activity and inhibits prostate cell growth.

Biological Activity

aim-100 is a small inhibitor of ack1 tyrosine kinase with ic50 value of 24 nm [1].aim-100 mimicked atp and inhibited the activity of ack1 significantly and specifically. it showed no inhibition activity for the other 30 kinases including pi3-kinase and akt, and showed a five-fold higher ic50 value for lck. in mef cells treated with egf, aim-100 caused a remarkable decrease of the activation of ack1. in the human prostate cancer cells lncap and lapc4, aim-100 treatment resulted in an increase of g0/g1 cell phase and subsequent cell growth suppression. these effects of aim-100 also exerted in the pancreatic cancer cells. aim-100 induced apoptosis in panc-1 cells at concentration of 10 μm. moreover, aim-100 inhibited cell growth with gi50 values of 7 to 8 μm in cd-18, panc-1, ov90, mcf-7 and mda-mb-468 cancer cells [1, 2].

storage

Store at +4°C

References

1. mahajan k, challa s, coppola d, et al. effect of ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity. the prostate, 2010, 70(12): 1274-1285. 2. mahajan k, coppola d, chen y, et al. ack1 tyrosine kinase activation correlates with pancreatic cancer progression. the american journal of pathology, 2012, 180(4): 1386-1393.

AIM-100 Preparation Products And Raw materials

Raw materials

Preparation Products

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AIM-100 Suppliers

China 61 India 1 The Netherlands 1 United Kingdom 1 United States 12 Global 76

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354
Email: support@targetmol.com
Country: United States
ProdList: 19973
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

873305-35-2, AIM-100Related Search:

Sulfanilamide 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol Deionized water (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride

AIM-100

5,6-Diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]furo[2,3-d]pyrimidin-4-amine

AIM 100;AIM100

Furo[2,3-d]pyrimidin-4-amine, 5,6-diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]-

(S)-5,6-Diphenyl-N-((tetrahydrofuran-2-yl)methyl)furo[2,3-d]pyrimidin-4-amine

TMPRSS2,AIM-100,AIM 100,Inhibitor,Ack1,NKX3.1,TNK2,ATM,Activated Cdc42 kinase 1,Tyr-phosphorylation,PSA,Tyr267,inhibit,anticancer

(S)-5,6-Diphenyl-N-[(2-tetrahydrofuryl)methyl]furo[2,3-d]pyrimidin-4-amine

873305-35-2

API